NEET · BiologyHard
If the concentration of antidiuretic hormone (ADH) in the blood is significantly elevated, what specific change occurs in the permeability of the nephron segments?
- A.Increased insertion of aquaporin-2 channels into the apical membrane of the collecting duct
- B.Decreased permeability of the proximal convoluted tubule to water
- C.Increased permeability of the ascending limb of the loop of Henle to water
- D.Decreased urea transporter activity in the inner medullary collecting duct
Show correct answer & step-by-step solution
Correct answer: A — Increased insertion of aquaporin-2 channels into the apical membrane of the collecting duct
Solution
- ADH binds to V2 receptors on the basolateral membrane of collecting duct cells.
- This triggers a signaling cascade involving cyclic AMP.
- Vesicles containing aquaporin-2 channels fuse with the apical membrane.
- This increases the water permeability of the collecting duct epithelium.
- Hence the answer is (A).
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