NEET · BiologyHard
In the Golgi apparatus, the sorting of lysosomal enzymes depends on the addition of a specific tag. Which chemical modification serves as this signal?
- A.Addition of N-acetylglucosamine-1-phosphate to mannose residues
- B.Sulfation of tyrosine residues
- C.Addition of sialic acid to the terminal galactose
- D.Phosphorylation of serine residues in the signal peptide
Show correct answer & step-by-step solution
Correct answer: A — Addition of N-acetylglucosamine-1-phosphate to mannose residues
Solution
- Lysosomal enzymes are synthesized in the rough ER.
- In the cis-Golgi, N-acetylglucosamine phosphotransferase adds N-acetylglucosamine-1-phosphate to mannose residues.
- A second enzyme removes the N-acetylglucosamine, leaving a mannose-6-phosphate tag.
- This tag is recognized by mannose-6-phosphate receptors for transport to the lysosome.
- Hence the answer is (A).
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