NEET · BiologyHard

Which enzyme is responsible for the conversion of pyruvate to acetyl-CoA, and what is the specific requirement for its activity?

  1. A.Pyruvate carboxylase requiring biotin
  2. B.Pyruvate dehydrogenase complex requiring NAD+ and CoA
  3. C.Pyruvate decarboxylase requiring TPP
  4. D.Pyruvate kinase requiring Mg2+
Show correct answer & step-by-step solution

Correct answer: BPyruvate dehydrogenase complex requiring NAD+ and CoA

Solution

  1. The reaction is .
  2. This reaction is catalyzed by the pyruvate dehydrogenase complex.
  3. The complex requires as an electron acceptor and as a substrate.
  4. Hence the answer is (B).

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