NEET · BiologyHard
In the process of RNA interference (RNAi) used for silencing genes in nematodes, what is the role of the enzyme Dicer?
- A.It unwinds the double-stranded RNA into single-stranded RNA
- B.It cleaves long double-stranded RNA into short interfering RNA (siRNA) fragments
- C.It facilitates the binding of siRNA to the target mRNA
- D.It degrades the target mRNA after the siRNA has hybridized to it
Show correct answer & step-by-step solution
Correct answer: B — It cleaves long double-stranded RNA into short interfering RNA (siRNA) fragments
Solution
- RNA interference is a post-transcriptional gene silencing mechanism.
- The enzyme Dicer recognizes long double-stranded RNA molecules.
- Dicer cleaves these molecules into smaller fragments known as short interfering RNAs (siRNAs).
- These siRNAs are then incorporated into the RISC complex to target complementary mRNA.
- Hence the answer is (B).
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